Cargando…

Physiological lentiviral vectors for the generation of improved CAR-T cells

Mostrar otras versiones (1)

Anti-CD19 chimeric antigen receptor (CAR)-T cells have achieved impressive outcomes for the treatment of relapsed and refractory B-lineage neoplasms. However, important limitations still remain due to severe adverse events (i.e., cytokine release syndrome and neuroinflammation) and relapse of 40%–50...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tristán-Manzano, María, Maldonado-Pérez, Noelia, Justicia-Lirio, Pedro, Muñoz, Pilar, Cortijo-Gutiérrez, Marina, Pavlovic, Kristina, Jiménez-Moreno, Rosario, Nogueras, Sonia, Carmona, M. Dolores, Sánchez-Hernández, Sabina, Aguilar-González, Araceli, Castella, María, Juan, Manel, Marañón, Concepción, Marchal, Juan Antonio, Benabdellah, Karim, Herrera, Concha, Martin, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163403/ https://www.ncbi.nlm.nih.gov/pubmed/35694446 http://dx.doi.org/10.1016/j.omto.2022.05.003

Ejemplares similares

Physiological lentiviral vectors for the generation of improved CAR-T cells
por: Tristán-Manzano, María, et al.
Publicado: (2022)

Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells
por: Tristán-Manzano, María, et al.
Publicado: (2023)

Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma
por: Maldonado-Pérez, Noelia, et al.
Publicado: (2022)

Using Gene Editing Approaches to Fine-Tune the Immune System
por: Pavlovic, Kristina, et al.
Publicado: (2020)

Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS(2) Protein Docks
por: Cortijo-Gutiérrez, Marina, et al.
Publicado: (2021)

Externally-Controlled Systems for Immunotherapy: From Bench to Bedside
por: Tristán-Manzano, María, et al.
Publicado: (2020)

Genome‐edited adult stem cells: Next‐generation advanced therapy medicinal products
por: Benabdellah, Karim, et al.
Publicado: (2020)

Failure of ALL recognition by CAR T cells: a review of CD 19-negative relapses after anti-CD 19 CAR-T treatment in B-ALL
por: Aparicio-Pérez, Clara, et al.
Publicado: (2023)

Exosome: A New Player in Translational Nanomedicine
por: Aheget, Houssam, et al.
Publicado: (2020)

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes
por: Sánchez-Hernández, Sabina, et al.
Publicado: (2018)

Development of Cellular Models to Study Efficiency and Safety of Gene Edition by Homologous Directed Recombination Using the CRISPR/Cas9 System
por: Sánchez-Hernández, Sabina, et al.
Publicado: (2020)

The Black Hole: CAR T Cell Therapy in AML
por: Atilla, Erden, et al.
Publicado: (2023)

Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells
por: Benabdellah, Karim, et al.
Publicado: (2016)

Large-Scale Production of Lentiviral Vectors: Current Perspectives and Challenges
por: Martínez-Molina, Eduardo, et al.
Publicado: (2020)

Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells
por: Huckaby, Justin T, et al.
Publicado: (2021)

Production of human CAR-NK cells with lentiviral vectors and functional assessment in vitro
por: Portillo, Ana L., et al.
Publicado: (2021)

Development of an All-in-One Lentiviral Vector System Based on the Original TetR for the Easy Generation of Tet-ON Cell Lines
por: Benabdellah, Karim, et al.
Publicado: (2011)

Establishing functional lentiviral vector production in a stirred bioreactor for CAR-T cell therapy
por: Tang, Qu-Lai, et al.
Publicado: (2021)

A Chimeric HS4-SAR Insulator (IS2) That Prevents Silencing and Enhances Expression of Lentiviral Vectors in Pluripotent Stem Cells
por: Benabdellah, Karim, et al.
Publicado: (2014)

Chimeric Antigen Receptor T Cells Targeting CD19 and Ibrutinib for Chronic Lymphocytic Leukemia
por: Delgado, Julio, et al.
Publicado: (2019)

Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors
por: Braun, Angela H., et al.
Publicado: (2022)

Specific Marking of hESCs-Derived Hematopoietic Lineage by WAS-Promoter Driven Lentiviral Vectors
por: Muñoz, Pilar, et al.
Publicado: (2012)

Inmunoterapia CAR-T en hemato-oncología pediátrica… presente y futuro
por: Juan, Manel, et al.
Publicado: (2020)

The Race of CAR Therapies: CAR-NK Cells for Fighting B-Cell Hematological Cancers
por: Herrera, Lara, et al.
Publicado: (2021)

Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics
por: Charitidis, Filippos T., et al.
Publicado: (2021)

Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics
por: Charitidis, Filippos T., et al.
Publicado: (2022)

BSCI-19 A LENTIVIRAL CRISPR SCREEN FOR EPIGENETIC MODULATORS OF ANTIGENS TARGETED BY CAR T CELLS IN GLIOBLASTOMA
por: Jordan Walter, T, et al.
Publicado: (2022)

Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering
por: Michels, Kathryn R, et al.
Publicado: (2023)

Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases
por: Aheget, Houssam, et al.
Publicado: (2020)

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors
por: Jamali, Arezoo, et al.
Publicado: (2019)

Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
por: Picanço-Castro, Virgínia, et al.
Publicado: (2020)

Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells
por: Cordes, Nicole, et al.
Publicado: (2021)

Manufacturing and Management of CAR T-Cell Therapy in “COVID-19’s Time”: Central Versus Point of Care Proposals
por: Ortiz de Landazuri, Iñaki, et al.
Publicado: (2020)

Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
por: Nogueras Pérez, Raquel, et al.
Publicado: (2023)

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources
por: Schmidts, Andrea, et al.
Publicado: (2020)

P1363: NOVEL DUAL-TARGETING AND SURFACE-ENGINEERED BIO-ORTHOGONALLY LENTIVIRAL VECTORS FOR IN VIVO CAR-T CELLS GENERATION
por: Chen, Zhaozhao, et al.
Publicado: (2023)

Molecular Detection of Rickettsia typhi in Cats and Fleas
por: Nogueras, Maria Mercedes, et al.
Publicado: (2013)

WAS Promoter-Driven Lentiviral Vectors Mimic Closely the Lopsided WASP Expression during Megakaryocytic Differentiation
por: Muñoz, Pilar, et al.
Publicado: (2020)

CAR-T after Stem Cell Transplantation in B-Cell Lymphoproliferative Disorders: Are They Really Autologous or Allogenic Cell Therapies?
por: Bartoló-Ibars, Ariadna, et al.
Publicado: (2021)

Production of lentiviral vectors
por: Merten, Otto-Wilhelm, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8je9shkugdn7uqj3opflnv0gue