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Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges

Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics are commonly used to evaluate the conditions of various diseases especially in tumors. Accumulating evidence supports that ferroptosis can regulate tumor development, metastasis, and therapeutic responses. Co...

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Autores principales: Nie, Zhenyu, Chen, Mei, Gao, Yuanhui, Huang, Denggao, Cao, Hui, Peng, Yanling, Guo, Na, Wang, Fei, Zhang, Shufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163417/
https://www.ncbi.nlm.nih.gov/pubmed/35668934
http://dx.doi.org/10.3389/fphar.2022.879317
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author Nie, Zhenyu
Chen, Mei
Gao, Yuanhui
Huang, Denggao
Cao, Hui
Peng, Yanling
Guo, Na
Wang, Fei
Zhang, Shufang
author_facet Nie, Zhenyu
Chen, Mei
Gao, Yuanhui
Huang, Denggao
Cao, Hui
Peng, Yanling
Guo, Na
Wang, Fei
Zhang, Shufang
author_sort Nie, Zhenyu
collection PubMed
description Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics are commonly used to evaluate the conditions of various diseases especially in tumors. Accumulating evidence supports that ferroptosis can regulate tumor development, metastasis, and therapeutic responses. Considering to the important role of chemotherapy in tumor treatment, drug resistance has become the most serious challenge. Revealing the molecular mechanism of ferroptosis is expected to solve tumor drug resistance and find new therapies to treat cancers. In this review, we discuss the relationship between ferroptosis and tumor drug resistance, summarize the abnormal ferroptosis in tissues of different cancer types and current research progress and challenges in overcoming treatment resistance, and explore the concept of targeting ferroptosis to improve tumor treatment outcomes.
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spelling pubmed-91634172022-06-05 Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges Nie, Zhenyu Chen, Mei Gao, Yuanhui Huang, Denggao Cao, Hui Peng, Yanling Guo, Na Wang, Fei Zhang, Shufang Front Pharmacol Pharmacology Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics are commonly used to evaluate the conditions of various diseases especially in tumors. Accumulating evidence supports that ferroptosis can regulate tumor development, metastasis, and therapeutic responses. Considering to the important role of chemotherapy in tumor treatment, drug resistance has become the most serious challenge. Revealing the molecular mechanism of ferroptosis is expected to solve tumor drug resistance and find new therapies to treat cancers. In this review, we discuss the relationship between ferroptosis and tumor drug resistance, summarize the abnormal ferroptosis in tissues of different cancer types and current research progress and challenges in overcoming treatment resistance, and explore the concept of targeting ferroptosis to improve tumor treatment outcomes. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9163417/ /pubmed/35668934 http://dx.doi.org/10.3389/fphar.2022.879317 Text en Copyright © 2022 Nie, Chen, Gao, Huang, Cao, Peng, Guo, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Nie, Zhenyu
Chen, Mei
Gao, Yuanhui
Huang, Denggao
Cao, Hui
Peng, Yanling
Guo, Na
Wang, Fei
Zhang, Shufang
Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
title Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
title_full Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
title_fullStr Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
title_full_unstemmed Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
title_short Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
title_sort ferroptosis and tumor drug resistance: current status and major challenges
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163417/
https://www.ncbi.nlm.nih.gov/pubmed/35668934
http://dx.doi.org/10.3389/fphar.2022.879317
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