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Poor ovarian response is associated with air pollutants: A multicentre study in China

BACKGROUND: Human evidence on the association between air pollution and ovarian response is scarce. Poor ovarian response (POR) with an incidence of 5–35% is a tricky problem in IVF treatment. METHODS: In this large-scale multicentre study, we included 2186 women with POR (< 4 oocytes retrieved)...

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Autores principales: Wu, Shanshan, Hao, Guimin, Zhang, Yunshan, Chen, Xiujuan, Ren, Haiqin, Fan, Yanli, Zhang, Yinfeng, Bi, Xingyu, Du, Chen, Bai, Lina, Wu, Xueqing, Tan, Jichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163489/
https://www.ncbi.nlm.nih.gov/pubmed/35660784
http://dx.doi.org/10.1016/j.ebiom.2022.104084
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author Wu, Shanshan
Hao, Guimin
Zhang, Yunshan
Chen, Xiujuan
Ren, Haiqin
Fan, Yanli
Zhang, Yinfeng
Bi, Xingyu
Du, Chen
Bai, Lina
Wu, Xueqing
Tan, Jichun
author_facet Wu, Shanshan
Hao, Guimin
Zhang, Yunshan
Chen, Xiujuan
Ren, Haiqin
Fan, Yanli
Zhang, Yinfeng
Bi, Xingyu
Du, Chen
Bai, Lina
Wu, Xueqing
Tan, Jichun
author_sort Wu, Shanshan
collection PubMed
description BACKGROUND: Human evidence on the association between air pollution and ovarian response is scarce. Poor ovarian response (POR) with an incidence of 5–35% is a tricky problem in IVF treatment. METHODS: In this large-scale multicentre study, we included 2186 women with POR (< 4 oocytes retrieved) and 7033 women with a normal ovarian response (10–15 oocytes retrieved), who underwent their first in vitro fertilization treatment in five cities in northern China during 2015–2020. Average concentrations of six air pollutants (PM(2.5), PM(10), O(3), NO(2), CO, and SO(2)) during different exposure windows (5 days, 1, 3, 6, and 12 months) before oocyte pick up (OPU) were calculated using data from the air monitoring station nearest to the residential site as approximate individual exposure. Logistic regression models were employed to assess the association between exposure to air pollutants and the risk of POR. Stratification analyses were conducted based on female age. Sensitivity analyses were performed in poor responders identified by Bologna criteria and women with unexpected POR. FINDINGS: We detected that increased SO(2) exposure during all exposure windows before OPU was associated with a higher risk of POR, especially for women ≤ 30 years old. In the stratified analysis, the effect sizes were larger for the unexpected poor ovarian response. INTERPRETATION: The findings provide human evidence for adverse effects of exposure to ambient air pollutants on ovarian response and underscore the need to reduce ambient air pollution exposure in women of reproductive age to protect human fertility. FUNDING: This study was granted from the National Key Research and Development Program (2018YFC1004203), the Major Special Construction Plan for Discipline Construction Project of China Medical University (3110118033), the Shengjing Freelance Researcher Plan of Shengjing Hospital of China Medical University, and the National Natural Science Foundation of China (82071601), the Central Government Special Fund for Local Science and Technology Development (2020JH6/10500006).
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spelling pubmed-91634892022-06-22 Poor ovarian response is associated with air pollutants: A multicentre study in China Wu, Shanshan Hao, Guimin Zhang, Yunshan Chen, Xiujuan Ren, Haiqin Fan, Yanli Zhang, Yinfeng Bi, Xingyu Du, Chen Bai, Lina Wu, Xueqing Tan, Jichun eBioMedicine Articles BACKGROUND: Human evidence on the association between air pollution and ovarian response is scarce. Poor ovarian response (POR) with an incidence of 5–35% is a tricky problem in IVF treatment. METHODS: In this large-scale multicentre study, we included 2186 women with POR (< 4 oocytes retrieved) and 7033 women with a normal ovarian response (10–15 oocytes retrieved), who underwent their first in vitro fertilization treatment in five cities in northern China during 2015–2020. Average concentrations of six air pollutants (PM(2.5), PM(10), O(3), NO(2), CO, and SO(2)) during different exposure windows (5 days, 1, 3, 6, and 12 months) before oocyte pick up (OPU) were calculated using data from the air monitoring station nearest to the residential site as approximate individual exposure. Logistic regression models were employed to assess the association between exposure to air pollutants and the risk of POR. Stratification analyses were conducted based on female age. Sensitivity analyses were performed in poor responders identified by Bologna criteria and women with unexpected POR. FINDINGS: We detected that increased SO(2) exposure during all exposure windows before OPU was associated with a higher risk of POR, especially for women ≤ 30 years old. In the stratified analysis, the effect sizes were larger for the unexpected poor ovarian response. INTERPRETATION: The findings provide human evidence for adverse effects of exposure to ambient air pollutants on ovarian response and underscore the need to reduce ambient air pollution exposure in women of reproductive age to protect human fertility. FUNDING: This study was granted from the National Key Research and Development Program (2018YFC1004203), the Major Special Construction Plan for Discipline Construction Project of China Medical University (3110118033), the Shengjing Freelance Researcher Plan of Shengjing Hospital of China Medical University, and the National Natural Science Foundation of China (82071601), the Central Government Special Fund for Local Science and Technology Development (2020JH6/10500006). Elsevier 2022-05-31 /pmc/articles/PMC9163489/ /pubmed/35660784 http://dx.doi.org/10.1016/j.ebiom.2022.104084 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles
Wu, Shanshan
Hao, Guimin
Zhang, Yunshan
Chen, Xiujuan
Ren, Haiqin
Fan, Yanli
Zhang, Yinfeng
Bi, Xingyu
Du, Chen
Bai, Lina
Wu, Xueqing
Tan, Jichun
Poor ovarian response is associated with air pollutants: A multicentre study in China
title Poor ovarian response is associated with air pollutants: A multicentre study in China
title_full Poor ovarian response is associated with air pollutants: A multicentre study in China
title_fullStr Poor ovarian response is associated with air pollutants: A multicentre study in China
title_full_unstemmed Poor ovarian response is associated with air pollutants: A multicentre study in China
title_short Poor ovarian response is associated with air pollutants: A multicentre study in China
title_sort poor ovarian response is associated with air pollutants: a multicentre study in china
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163489/
https://www.ncbi.nlm.nih.gov/pubmed/35660784
http://dx.doi.org/10.1016/j.ebiom.2022.104084
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