Subacute effects of hydroethanolic extracts of the pulp of Gambeya africana on glucose plasmatic levels and oxidative stress markers in diabetic rats

The management of hyperglycemia and oxidative stress is a key point in the control of diabetes and its complications. The work evaluated the hypoglycemiant and antioxidant properties of pulp extracts of Gambeya africana fruits. The acute toxicity was conducted for 14 days at the dose of 2000 mg/kg via oral gavage. Diabetes was induced in rats by intravenous administration of streptozotocin (50 mg/kg). The effect of the extract on blood glucose levels of diabetic rats was monitored at 2h after administration; and on the 7th and 14th days of treatment (single dose of 400 mg/kg/day). After 2 weeks of treatment, the rats were sacrificed. The oxidative stress markers (Hydroperoxides, Malonedialdehydes, Superoxide Dismutase, Catalase, and Total Antioxidant Capacity) and hepato/nephrotoxicity markers (Alanine Amino Transferase, urea, and creatinine) were determined. The hydroethanolic extract of G. africana fruits has a lethal dose upper than 2000 mg/kg. It significantly decreased glucose levels by 28.29% and 84.86% respectively after 2h and 14th days of treatment. The extract increased the antioxidant status and decrease oxidative stress, especially in the pancreas. This study suggests that the hydroethanolic pulp extract of G. africana fruits is a good hypoglycemiant and antioxidant agent and could be a potential source of compounds for diabetes management.