Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia

The optimal therapy for relapsed primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS) remains unclear. We herein report a case of relapsed primary DLBCL of the CNS complicated with primary biliary cholangitis, cirrhosis, and pancytopenia that was successfully treated wit...

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Detalles Bibliográficos
Autores principales: Nakagawa, Noriharu, Yamano, Ruiko, Kajikawa, Sayaka, Kondo, Yukio, Okumura, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163585/
https://www.ncbi.nlm.nih.gov/pubmed/35669930
http://dx.doi.org/10.1016/j.lrr.2022.100331
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author Nakagawa, Noriharu
Yamano, Ruiko
Kajikawa, Sayaka
Kondo, Yukio
Okumura, Hirokazu
author_facet Nakagawa, Noriharu
Yamano, Ruiko
Kajikawa, Sayaka
Kondo, Yukio
Okumura, Hirokazu
author_sort Nakagawa, Noriharu
collection PubMed
description The optimal therapy for relapsed primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS) remains unclear. We herein report a case of relapsed primary DLBCL of the CNS complicated with primary biliary cholangitis, cirrhosis, and pancytopenia that was successfully treated with bridging therapy with tirabrutinib before autologous hematopoietic stem cell transplantation (ASCT). Tirabrutinib is well tolerated and effective for relapsed primary DLBCL of the CNS with comorbidities, including cirrhosis and pancytopenia. Tirabrutinib is a promising option as bridging therapy before ASCT.
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spelling pubmed-91635852022-06-05 Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia Nakagawa, Noriharu Yamano, Ruiko Kajikawa, Sayaka Kondo, Yukio Okumura, Hirokazu Leuk Res Rep Article The optimal therapy for relapsed primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS) remains unclear. We herein report a case of relapsed primary DLBCL of the CNS complicated with primary biliary cholangitis, cirrhosis, and pancytopenia that was successfully treated with bridging therapy with tirabrutinib before autologous hematopoietic stem cell transplantation (ASCT). Tirabrutinib is well tolerated and effective for relapsed primary DLBCL of the CNS with comorbidities, including cirrhosis and pancytopenia. Tirabrutinib is a promising option as bridging therapy before ASCT. Elsevier 2022-05-30 /pmc/articles/PMC9163585/ /pubmed/35669930 http://dx.doi.org/10.1016/j.lrr.2022.100331 Text en © 2022 The Author(s). Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nakagawa, Noriharu
Yamano, Ruiko
Kajikawa, Sayaka
Kondo, Yukio
Okumura, Hirokazu
Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia
title Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia
title_full Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia
title_fullStr Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia
title_full_unstemmed Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia
title_short Successful bridging therapy with tirabrutinib before ASCT for relapsed primary DLBCL of the CNS complicated with PBC, cirrhosis, and pancytopenia
title_sort successful bridging therapy with tirabrutinib before asct for relapsed primary dlbcl of the cns complicated with pbc, cirrhosis, and pancytopenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163585/
https://www.ncbi.nlm.nih.gov/pubmed/35669930
http://dx.doi.org/10.1016/j.lrr.2022.100331
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