Cargando…

Receptor-Dependent Endocytosis Mediates α-Synuclein Oligomer Transport Into Red Blood Cells

Detection of oligomeric α-synuclein (o-α-Syn) in red blood cells (RBCs) has been shown to be promising in diagnosing Parkinson’s disease and other synucleinopathies. However, if RBC o-α-Syn derive from plasma and can reflect changes of plasma o-α-Syn remains unclear. In this study, synthetic o-α-Syn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wei, Hu, Junya, Li, Xin, Lu, Zhe, Li, Xuying, Wang, Chaodong, Yu, Shun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163663/ https://www.ncbi.nlm.nih.gov/pubmed/35669464 http://dx.doi.org/10.3389/fnagi.2022.899892

Ejemplares similares

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling
por: Huang, Mingzhu, et al.
Publicado: (2019)

Detrimental effects of soluble α-synuclein oligomers at excitatory glutamatergic synapses
por: Ferrari, Elena, et al.
Publicado: (2023)

Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability
por: Kaufmann, Timothy J., et al.
Publicado: (2016)

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
por: Limbocker, Ryan, et al.
Publicado: (2021)

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
por: Anderson, Eric N., et al.
Publicado: (2020)

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers
por: Aasly, Jan O., et al.
Publicado: (2014)

Quantifying Co-Oligomer Formation by α-Synuclein
por: Iljina, Marija, et al.
Publicado: (2018)

The Role of α-Synuclein Oligomers in Parkinson’s Disease
por: Du, Xiao-yu, et al.
Publicado: (2020)

Stabilization of α-synuclein oligomers using formaldehyde
por: Ruesink, Harm, et al.
Publicado: (2019)

Dopamine prevents lipid peroxidation-induced accumulation of toxic α-synuclein oligomers by preserving autophagy-lysosomal function
por: Jiang, Peizhou, et al.
Publicado: (2013)

Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein
por: Martinez Hernandez, Ana, et al.
Publicado: (2021)

Alterations of Erythrocytic Phosphorylated Alpha-Synuclein in Different Subtypes and Stages of Parkinson's Disease
por: Li, Xu-Ying, et al.
Publicado: (2021)

Structural characteristics and membrane interactions of tandem α-synuclein oligomers
por: Dong, Chunhua, et al.
Publicado: (2018)

Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains
por: Yang, Weiwei, et al.
Publicado: (2016)

Structural and functional properties of prefibrillar α-synuclein oligomers
por: Pieri, Laura, et al.
Publicado: (2016)

Optical Structural Analysis of Individual α‐Synuclein Oligomers
por: Varela, Juan A., et al.
Publicado: (2018)

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
por: Lee, Ji-Eun, et al.
Publicado: (2018)

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023)

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
por: Wijesekara, Nadeeja, et al.
Publicado: (2021)

Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution
por: Awasthi, Saurabh, et al.
Publicado: (2023)

Phosphorylated Alpha-Synuclein in Red Blood Cells as a Potential Diagnostic Biomarker for Multiple System Atrophy: A Pilot Study
por: Li, Xu-Ying, et al.
Publicado: (2020)

Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons
por: Tomagra, Giulia, et al.
Publicado: (2023)

α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson’s Disease Patients and Correlate with Disease Severity
por: Daniele, Simona, et al.
Publicado: (2018)

Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution
por: Li, Xi, et al.
Publicado: (2019)

DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein
por: Atieh, Tamr B., et al.
Publicado: (2021)

Versatile Structures of α-Synuclein
por: Wang, Chuchu, et al.
Publicado: (2016)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
por: Mor, Danielle E., et al.
Publicado: (2017)

Photo-Induced Cross-Linking of Unmodified α-Synuclein Oligomers
por: Ortigosa-Pascual, Lei, et al.
Publicado: (2023)

α-Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity
por: Fecchio, Chiara, et al.
Publicado: (2013)

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
por: Gerson, Julia E., et al.
Publicado: (2018)

ELISA method to detect α-synuclein oligomers in cell and animal models
por: Lassen, Louise Berkhoudt, et al.
Publicado: (2018)

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
por: Castillo-Carranza, Diana L., et al.
Publicado: (2018)

Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC
por: Palazzi, Luana, et al.
Publicado: (2021)

DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers
por: Jin, Mingyue, et al.
Publicado: (2022)

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers
por: Wu, Shenjie, et al.
Publicado: (2023)

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease
por: Garcia-Esparcia, Paula, et al.
Publicado: (2015)

Corrigendum: Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons
por: Tomagra, Giulia, et al.
Publicado: (2023)

α-Synuclein Alters Toll-Like Receptor Expression
por: Béraud, Dawn, et al.
Publicado: (2011)

Lighting Up Alpha-synuclein Oligomers
por: Richter, Franziska
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ise7748kq9htlp9s2e16705tl3