Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics

Metal-ion-based self-assembly supramolecular theranostics exhibit excellent performance in biomedical applications owing to their potential superiorities for simultaneous precise diagnosis, targeted drug delivery, and monitoring the response to therapy in real-time. Specially, the rational designed...

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Autores principales: Chen, Bing, Chu, Chengchao, Ren, En, Lin, Huirong, Zhang, Yang, Wang, Peiyu, Yao, Hong, Liu, Ailin, Liu, Gang, Lin, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163678/
https://www.ncbi.nlm.nih.gov/pubmed/35668829
http://dx.doi.org/10.3389/fchem.2022.870769
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author Chen, Bing
Chu, Chengchao
Ren, En
Lin, Huirong
Zhang, Yang
Wang, Peiyu
Yao, Hong
Liu, Ailin
Liu, Gang
Lin, Xinhua
author_facet Chen, Bing
Chu, Chengchao
Ren, En
Lin, Huirong
Zhang, Yang
Wang, Peiyu
Yao, Hong
Liu, Ailin
Liu, Gang
Lin, Xinhua
author_sort Chen, Bing
collection PubMed
description Metal-ion-based self-assembly supramolecular theranostics exhibit excellent performance in biomedical applications owing to their potential superiorities for simultaneous precise diagnosis, targeted drug delivery, and monitoring the response to therapy in real-time. Specially, the rational designed systems could achieve specific in vivo self-assembly through complexation or ionic interaction to improve tissue-specific accumulation, penetration, and cell internalization, thereby reducing toxicities of drugs in diagnostics and therapy. Furthermore, such imaging traceable nanosystems could provide real-timely information of drug accumulation and therapeutic effects in a non-invasive and safe manner. Herein, the article highlights the recent prominent applications based on the metal ions self-assembly in cancer treatment. This strategy may open up new research directions to develop novel drug delivery systems for cancer theranostics.
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spelling pubmed-91636782022-06-05 Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics Chen, Bing Chu, Chengchao Ren, En Lin, Huirong Zhang, Yang Wang, Peiyu Yao, Hong Liu, Ailin Liu, Gang Lin, Xinhua Front Chem Chemistry Metal-ion-based self-assembly supramolecular theranostics exhibit excellent performance in biomedical applications owing to their potential superiorities for simultaneous precise diagnosis, targeted drug delivery, and monitoring the response to therapy in real-time. Specially, the rational designed systems could achieve specific in vivo self-assembly through complexation or ionic interaction to improve tissue-specific accumulation, penetration, and cell internalization, thereby reducing toxicities of drugs in diagnostics and therapy. Furthermore, such imaging traceable nanosystems could provide real-timely information of drug accumulation and therapeutic effects in a non-invasive and safe manner. Herein, the article highlights the recent prominent applications based on the metal ions self-assembly in cancer treatment. This strategy may open up new research directions to develop novel drug delivery systems for cancer theranostics. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9163678/ /pubmed/35668829 http://dx.doi.org/10.3389/fchem.2022.870769 Text en Copyright © 2022 Chen, Chu, Ren, Lin, Zhang, Wang, Yao, Liu, Liu and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Chen, Bing
Chu, Chengchao
Ren, En
Lin, Huirong
Zhang, Yang
Wang, Peiyu
Yao, Hong
Liu, Ailin
Liu, Gang
Lin, Xinhua
Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
title Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
title_full Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
title_fullStr Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
title_full_unstemmed Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
title_short Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
title_sort metal ion-based supramolecular self-assembly for cancer theranostics
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163678/
https://www.ncbi.nlm.nih.gov/pubmed/35668829
http://dx.doi.org/10.3389/fchem.2022.870769
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