Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s sarcoma herpes virus oncoprotein vFLIP

Constitutive activation of the canonical NF-κB signaling pathway is a major factor in Kaposi’s sarcoma-associated herpes virus pathogenesis where it is essential for the survival of primary effusion lymphoma. Central to this process is persistent upregulation of the inhibitor of κB kinase (IKK) comp...

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Detalles Bibliográficos
Autores principales: Bagnéris, Claire, Senthil Kumar, Swathi L., Baratchian, Mehdi, Britt, Hannah M., Assafa, Tufa E., Thalassinos, Konstantinos, Collins, Mary K., Barrett, Tracey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163697/
https://www.ncbi.nlm.nih.gov/pubmed/35525271
http://dx.doi.org/10.1016/j.jbc.2022.102012

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