Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation

Dysregulation of cyclin-dependent kinases (CDKs) can promote unchecked cell proliferation and cancer progression. Although focal adhesion kinase (FAK) contributes to regulating cell cycle progression, the exact molecular mechanism remains unclear. Here, we found that FAK plays a key role in cell cyc...

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Detalles Bibliográficos
Autores principales: Murphy, James M., Jeong, Kyuho, Ahn, Eun-Young Erin, Lim, Ssang-Taek Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163754/
https://www.ncbi.nlm.nih.gov/pubmed/35525274
http://dx.doi.org/10.1016/j.jbc.2022.102013

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