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Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Neurological Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163942/ https://www.ncbi.nlm.nih.gov/pubmed/35589317 http://dx.doi.org/10.3988/jcn.2022.18.3.280 |
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author | Kim, Ki Hoon Kim, Su-Hyun Hyun, Jae-Won Kim, Ho Jin |
author_facet | Kim, Ki Hoon Kim, Su-Hyun Hyun, Jae-Won Kim, Ho Jin |
author_sort | Kim, Ki Hoon |
collection | PubMed |
description | Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-most-common presentation in adults, followed by optic neuritis. While some features overlap, there are multiple reports of distinctive clinical and radiological features of MOG-IgG-associated myelitis, which are useful for differentiating MOGAD from both multiple sclerosis and neuromyelitis optica spectrum disorder. In this review we summarize the clinical and radiographic characteristics of MOG-IgG-associated myelitis with a particular focus on adult patients. |
format | Online Article Text |
id | pubmed-9163942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-91639422022-06-07 Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults Kim, Ki Hoon Kim, Su-Hyun Hyun, Jae-Won Kim, Ho Jin J Clin Neurol Review Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-most-common presentation in adults, followed by optic neuritis. While some features overlap, there are multiple reports of distinctive clinical and radiological features of MOG-IgG-associated myelitis, which are useful for differentiating MOGAD from both multiple sclerosis and neuromyelitis optica spectrum disorder. In this review we summarize the clinical and radiographic characteristics of MOG-IgG-associated myelitis with a particular focus on adult patients. Korean Neurological Association 2022-05 2022-04-28 /pmc/articles/PMC9163942/ /pubmed/35589317 http://dx.doi.org/10.3988/jcn.2022.18.3.280 Text en Copyright © 2022 Korean Neurological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kim, Ki Hoon Kim, Su-Hyun Hyun, Jae-Won Kim, Ho Jin Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults |
title | Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults |
title_full | Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults |
title_fullStr | Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults |
title_full_unstemmed | Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults |
title_short | Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults |
title_sort | clinical and radiological features of myelin oligodendrocyte glycoprotein-associated myelitis in adults |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163942/ https://www.ncbi.nlm.nih.gov/pubmed/35589317 http://dx.doi.org/10.3988/jcn.2022.18.3.280 |
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