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Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults

Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-...

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Autores principales: Kim, Ki Hoon, Kim, Su-Hyun, Hyun, Jae-Won, Kim, Ho Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163942/
https://www.ncbi.nlm.nih.gov/pubmed/35589317
http://dx.doi.org/10.3988/jcn.2022.18.3.280
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author Kim, Ki Hoon
Kim, Su-Hyun
Hyun, Jae-Won
Kim, Ho Jin
author_facet Kim, Ki Hoon
Kim, Su-Hyun
Hyun, Jae-Won
Kim, Ho Jin
author_sort Kim, Ki Hoon
collection PubMed
description Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-most-common presentation in adults, followed by optic neuritis. While some features overlap, there are multiple reports of distinctive clinical and radiological features of MOG-IgG-associated myelitis, which are useful for differentiating MOGAD from both multiple sclerosis and neuromyelitis optica spectrum disorder. In this review we summarize the clinical and radiographic characteristics of MOG-IgG-associated myelitis with a particular focus on adult patients.
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spelling pubmed-91639422022-06-07 Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults Kim, Ki Hoon Kim, Su-Hyun Hyun, Jae-Won Kim, Ho Jin J Clin Neurol Review Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-most-common presentation in adults, followed by optic neuritis. While some features overlap, there are multiple reports of distinctive clinical and radiological features of MOG-IgG-associated myelitis, which are useful for differentiating MOGAD from both multiple sclerosis and neuromyelitis optica spectrum disorder. In this review we summarize the clinical and radiographic characteristics of MOG-IgG-associated myelitis with a particular focus on adult patients. Korean Neurological Association 2022-05 2022-04-28 /pmc/articles/PMC9163942/ /pubmed/35589317 http://dx.doi.org/10.3988/jcn.2022.18.3.280 Text en Copyright © 2022 Korean Neurological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kim, Ki Hoon
Kim, Su-Hyun
Hyun, Jae-Won
Kim, Ho Jin
Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
title Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
title_full Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
title_fullStr Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
title_full_unstemmed Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
title_short Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
title_sort clinical and radiological features of myelin oligodendrocyte glycoprotein-associated myelitis in adults
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163942/
https://www.ncbi.nlm.nih.gov/pubmed/35589317
http://dx.doi.org/10.3988/jcn.2022.18.3.280
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