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Alterations of Functional Connectivity in Patients With Restless Legs Syndrome

Restless legs syndrome (RLS) is a common neurological illness marked by a strong desire to move one’s legs, usually in association with uncomfortable sensations. Recent studies have investigated brain networks and connectivity in RLS. The advent of network analysis has greatly improved our understan...

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Autores principales: Park, Kang Min, Kim, Keun Tae, Kang, Kyung Wook, Park, Jung A, Seo, Jong-Geun, Kim, Jiyoung, Chang, Hyeyeon, Kim, Eun Young, Cho, Yong Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163943/
https://www.ncbi.nlm.nih.gov/pubmed/35589318
http://dx.doi.org/10.3988/jcn.2022.18.3.290
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author Park, Kang Min
Kim, Keun Tae
Kang, Kyung Wook
Park, Jung A
Seo, Jong-Geun
Kim, Jiyoung
Chang, Hyeyeon
Kim, Eun Young
Cho, Yong Won
author_facet Park, Kang Min
Kim, Keun Tae
Kang, Kyung Wook
Park, Jung A
Seo, Jong-Geun
Kim, Jiyoung
Chang, Hyeyeon
Kim, Eun Young
Cho, Yong Won
author_sort Park, Kang Min
collection PubMed
description Restless legs syndrome (RLS) is a common neurological illness marked by a strong desire to move one’s legs, usually in association with uncomfortable sensations. Recent studies have investigated brain networks and connectivity in RLS. The advent of network analysis has greatly improved our understanding of the brain and various neurological disorders. A few studies have investigated alterations in functional connectivity in patients with RLS. This article reviews functional connectivity studies of patients with RLS, which have identified significant alterations relative to healthy controls in several brain networks including thalamic, salience, default-mode, and small-world networks. In addition, network changes related to RLS treatment have been found, including to repetitive transcranial magnetic stimulation, transcutaneous spinal cord direct-current stimulation, and dopaminergic drugs. These findings suggest that the underlying pathogenesis of RLS includes alterations in the functional connectivity in the brain and that RLS is a network disorder.
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spelling pubmed-91639432022-06-07 Alterations of Functional Connectivity in Patients With Restless Legs Syndrome Park, Kang Min Kim, Keun Tae Kang, Kyung Wook Park, Jung A Seo, Jong-Geun Kim, Jiyoung Chang, Hyeyeon Kim, Eun Young Cho, Yong Won J Clin Neurol Review Restless legs syndrome (RLS) is a common neurological illness marked by a strong desire to move one’s legs, usually in association with uncomfortable sensations. Recent studies have investigated brain networks and connectivity in RLS. The advent of network analysis has greatly improved our understanding of the brain and various neurological disorders. A few studies have investigated alterations in functional connectivity in patients with RLS. This article reviews functional connectivity studies of patients with RLS, which have identified significant alterations relative to healthy controls in several brain networks including thalamic, salience, default-mode, and small-world networks. In addition, network changes related to RLS treatment have been found, including to repetitive transcranial magnetic stimulation, transcutaneous spinal cord direct-current stimulation, and dopaminergic drugs. These findings suggest that the underlying pathogenesis of RLS includes alterations in the functional connectivity in the brain and that RLS is a network disorder. Korean Neurological Association 2022-05 2022-04-28 /pmc/articles/PMC9163943/ /pubmed/35589318 http://dx.doi.org/10.3988/jcn.2022.18.3.290 Text en Copyright © 2022 Korean Neurological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Park, Kang Min
Kim, Keun Tae
Kang, Kyung Wook
Park, Jung A
Seo, Jong-Geun
Kim, Jiyoung
Chang, Hyeyeon
Kim, Eun Young
Cho, Yong Won
Alterations of Functional Connectivity in Patients With Restless Legs Syndrome
title Alterations of Functional Connectivity in Patients With Restless Legs Syndrome
title_full Alterations of Functional Connectivity in Patients With Restless Legs Syndrome
title_fullStr Alterations of Functional Connectivity in Patients With Restless Legs Syndrome
title_full_unstemmed Alterations of Functional Connectivity in Patients With Restless Legs Syndrome
title_short Alterations of Functional Connectivity in Patients With Restless Legs Syndrome
title_sort alterations of functional connectivity in patients with restless legs syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163943/
https://www.ncbi.nlm.nih.gov/pubmed/35589318
http://dx.doi.org/10.3988/jcn.2022.18.3.290
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