Subtilisin of Leishmania amazonensis as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor

Subtilisin proteases, found in all organisms, are enzymes important in the post-translational steps of protein processing. In Leishmania major and L. donovani, this enzyme has been described as essential to their survival; however, few compounds that target subtilisin have been investigated for thei...

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Detalles Bibliográficos
Autores principales: Gomes, Pollyanna Stephanie, Carneiro, Monique Pacheco Duarte, Machado, Patrícia de Almeida, de Andrade-Neto, Valter Viana, da Fonseca-Martins, Alessandra Marcia, Goundry, Amy, Pereira da Silva, João Vitor Marques, Gomes, Daniel Claudio Oliveira, Lima, Ana Paula Cabral de Araujo, Ennes-Vidal, Vítor, Sodero, Ana Carolina Rennó, De-Simone, Salvatore Giovanni, de Matos Guedes, Herbert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164065/
https://www.ncbi.nlm.nih.gov/pubmed/35678670
http://dx.doi.org/10.3390/cimb44050141

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