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Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules

Duabanga grandiflora (DC.) Walp. is an ethnomedicinally significant plant used to treat various illnesses, but there is little scientific evidence to support its use. This study explored the pharmacological activities of methanol extract of D. grandiflora stem barks (MEDG) through in vivo approaches...

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Autores principales: Jahan, Israt, Khan, Mohammad Forhad, Sayeed, Mohammed Abu, Arshad, Laiba, Hossen, Md. Amjad, Jakaria, Md., Ağagündüz, Duygu, Haque, Md. Areeful, Capasso, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164075/
https://www.ncbi.nlm.nih.gov/pubmed/35678688
http://dx.doi.org/10.3390/cimb44050159
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author Jahan, Israt
Khan, Mohammad Forhad
Sayeed, Mohammed Abu
Arshad, Laiba
Hossen, Md. Amjad
Jakaria, Md.
Ağagündüz, Duygu
Haque, Md. Areeful
Capasso, Raffaele
author_facet Jahan, Israt
Khan, Mohammad Forhad
Sayeed, Mohammed Abu
Arshad, Laiba
Hossen, Md. Amjad
Jakaria, Md.
Ağagündüz, Duygu
Haque, Md. Areeful
Capasso, Raffaele
author_sort Jahan, Israt
collection PubMed
description Duabanga grandiflora (DC.) Walp. is an ethnomedicinally significant plant used to treat various illnesses, but there is little scientific evidence to support its use. This study explored the pharmacological activities of methanol extract of D. grandiflora stem barks (MEDG) through in vivo approaches in Swiss albino mice and a computer-aided molecular approach. The forced swimming test (FST), tail suspension test (TST), elevated plus maze (EPM), and hole board test (HBT) were used to determine anti-depressant and anxiolytic activity in experimental mice. In addition, anti-diarrheal studies were performed using castor oil-induced diarrhea, castor oil-induced enter pooling, and the charcoal-induced gastrointestinal motility test. MEDG showed substantial depletions in the immobility times in both FST and TST after treatment with the MEDG extract, whereas moderate anxiolytic activity was manifested at a higher dose (400 mg/kg) compared with the control. Correspondingly, MEDG extract revealed a significant reduction in wet feces and decreased the small intestinal transit of charcoal meal in castor oil-induced diarrhea and charcoal-induced gastrointestinal motility test. In the computer-aided molecular approaches, vanillin displayed a promising binding score for both anxiolytic and anti-diarrheal activities, while duabanganal C showed a promising score for the anti-depressant activity. The present experimental findings along with a computer-aided model conclude that MEDG could be a possible Phyto therapeutic agent with potential anti-depressant, anxiolytic and anti-diarrheal activity.
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spelling pubmed-91640752022-06-04 Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules Jahan, Israt Khan, Mohammad Forhad Sayeed, Mohammed Abu Arshad, Laiba Hossen, Md. Amjad Jakaria, Md. Ağagündüz, Duygu Haque, Md. Areeful Capasso, Raffaele Curr Issues Mol Biol Article Duabanga grandiflora (DC.) Walp. is an ethnomedicinally significant plant used to treat various illnesses, but there is little scientific evidence to support its use. This study explored the pharmacological activities of methanol extract of D. grandiflora stem barks (MEDG) through in vivo approaches in Swiss albino mice and a computer-aided molecular approach. The forced swimming test (FST), tail suspension test (TST), elevated plus maze (EPM), and hole board test (HBT) were used to determine anti-depressant and anxiolytic activity in experimental mice. In addition, anti-diarrheal studies were performed using castor oil-induced diarrhea, castor oil-induced enter pooling, and the charcoal-induced gastrointestinal motility test. MEDG showed substantial depletions in the immobility times in both FST and TST after treatment with the MEDG extract, whereas moderate anxiolytic activity was manifested at a higher dose (400 mg/kg) compared with the control. Correspondingly, MEDG extract revealed a significant reduction in wet feces and decreased the small intestinal transit of charcoal meal in castor oil-induced diarrhea and charcoal-induced gastrointestinal motility test. In the computer-aided molecular approaches, vanillin displayed a promising binding score for both anxiolytic and anti-diarrheal activities, while duabanganal C showed a promising score for the anti-depressant activity. The present experimental findings along with a computer-aided model conclude that MEDG could be a possible Phyto therapeutic agent with potential anti-depressant, anxiolytic and anti-diarrheal activity. MDPI 2022-05-20 /pmc/articles/PMC9164075/ /pubmed/35678688 http://dx.doi.org/10.3390/cimb44050159 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jahan, Israt
Khan, Mohammad Forhad
Sayeed, Mohammed Abu
Arshad, Laiba
Hossen, Md. Amjad
Jakaria, Md.
Ağagündüz, Duygu
Haque, Md. Areeful
Capasso, Raffaele
Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
title Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
title_full Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
title_fullStr Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
title_full_unstemmed Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
title_short Neuropharmacological and Antidiarrheal Potentials of Duabanga grandiflora (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
title_sort neuropharmacological and antidiarrheal potentials of duabanga grandiflora (dc.) walp. stem bark and prospective ligand–receptor interactions of its bioactive lead molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164075/
https://www.ncbi.nlm.nih.gov/pubmed/35678688
http://dx.doi.org/10.3390/cimb44050159
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