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Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment

For both human and veterinary patients, non-infectious intestinal disease is a major cause of morbidity and mortality. To improve treatment of intestinal disease, large animal models are increasingly recognized as critical tools to translate the basic science discoveries made in rodent models into c...

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Detalles Bibliográficos
Autores principales: Schaaf, Cecilia R., Gonzalez, Liara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164269/
https://www.ncbi.nlm.nih.gov/pubmed/35669174
http://dx.doi.org/10.3389/fvets.2022.878952
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author Schaaf, Cecilia R.
Gonzalez, Liara M.
author_facet Schaaf, Cecilia R.
Gonzalez, Liara M.
author_sort Schaaf, Cecilia R.
collection PubMed
description For both human and veterinary patients, non-infectious intestinal disease is a major cause of morbidity and mortality. To improve treatment of intestinal disease, large animal models are increasingly recognized as critical tools to translate the basic science discoveries made in rodent models into clinical application. Large animal intestinal models, particularly porcine, more closely resemble human anatomy, physiology, and disease pathogenesis; these features make them critical to the pre-clinical study of intestinal disease treatments. Previously, large animal model use has been somewhat precluded by the lack of genetically altered large animals to mechanistically investigate non-infectious intestinal diseases such as colorectal cancer, cystic fibrosis, and ischemia-reperfusion injury. However, recent advances and increased availability of gene editing technologies has led to both novel use of large animal models in clinically relevant intestinal disease research and improved testing of potential therapeutics for these diseases.
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spelling pubmed-91642692022-06-05 Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment Schaaf, Cecilia R. Gonzalez, Liara M. Front Vet Sci Veterinary Science For both human and veterinary patients, non-infectious intestinal disease is a major cause of morbidity and mortality. To improve treatment of intestinal disease, large animal models are increasingly recognized as critical tools to translate the basic science discoveries made in rodent models into clinical application. Large animal intestinal models, particularly porcine, more closely resemble human anatomy, physiology, and disease pathogenesis; these features make them critical to the pre-clinical study of intestinal disease treatments. Previously, large animal model use has been somewhat precluded by the lack of genetically altered large animals to mechanistically investigate non-infectious intestinal diseases such as colorectal cancer, cystic fibrosis, and ischemia-reperfusion injury. However, recent advances and increased availability of gene editing technologies has led to both novel use of large animal models in clinically relevant intestinal disease research and improved testing of potential therapeutics for these diseases. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9164269/ /pubmed/35669174 http://dx.doi.org/10.3389/fvets.2022.878952 Text en Copyright © 2022 Schaaf and Gonzalez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Schaaf, Cecilia R.
Gonzalez, Liara M.
Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
title Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
title_full Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
title_fullStr Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
title_full_unstemmed Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
title_short Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
title_sort use of translational, genetically modified porcine models to ultimately improve intestinal disease treatment
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164269/
https://www.ncbi.nlm.nih.gov/pubmed/35669174
http://dx.doi.org/10.3389/fvets.2022.878952
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