Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males

BACKGROUND: We hypothesized that a gender difference in clinical response may exist to adjuvant CTLA4 blockade with ipilimumab versus high-dose IFNα (HDI). We investigated differences in candidate immune biomarkers in the circulation and tumor microenvironment (TME). PATIENTS AND METHODS: This gende...

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Detalles Bibliográficos
Autores principales: Saad, Mariam, Lee, Sandra J., Tan, Aik Choon, El Naqa, Issam M., Hodi, F. Stephen, Butterfield, Lisa H., LaFramboise, William A., Storkus, Walter, Karunamurthy, Arivarasan D., Conejo-Garcia, Jose, Hwu, Patrick, Streicher, Howard, Sondak, Vernon K., Kirkwood, John M., Tarhini, Ahmad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164320/
https://www.ncbi.nlm.nih.gov/pubmed/35659704
http://dx.doi.org/10.1186/s12967-022-03450-3

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