Defective mitophagy and the etiopathogenesis of Alzheimer’s disease

Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer’s disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development....

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Kuan, Yu, Xuan, Mahaman, Yacoubou Abdoul Razak, Wang, Jian-Zhi, Liu, Rong, Li, Yi, Wang, Xiaochuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164340/
https://www.ncbi.nlm.nih.gov/pubmed/35655270
http://dx.doi.org/10.1186/s40035-022-00305-1
_version_ 1784720112363765760
author Zeng, Kuan
Yu, Xuan
Mahaman, Yacoubou Abdoul Razak
Wang, Jian-Zhi
Liu, Rong
Li, Yi
Wang, Xiaochuan
author_facet Zeng, Kuan
Yu, Xuan
Mahaman, Yacoubou Abdoul Razak
Wang, Jian-Zhi
Liu, Rong
Li, Yi
Wang, Xiaochuan
author_sort Zeng, Kuan
collection PubMed
description Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer’s disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development. The interaction between mitophagy deficits and Aβ or Tau pathology may form a vicious cycle and cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD. Defective mitophagy is a potential target for AD prevention and treatment.
format Online
Article
Text
id pubmed-9164340
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-91643402022-06-05 Defective mitophagy and the etiopathogenesis of Alzheimer’s disease Zeng, Kuan Yu, Xuan Mahaman, Yacoubou Abdoul Razak Wang, Jian-Zhi Liu, Rong Li, Yi Wang, Xiaochuan Transl Neurodegener Review Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer’s disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development. The interaction between mitophagy deficits and Aβ or Tau pathology may form a vicious cycle and cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD. Defective mitophagy is a potential target for AD prevention and treatment. BioMed Central 2022-06-03 /pmc/articles/PMC9164340/ /pubmed/35655270 http://dx.doi.org/10.1186/s40035-022-00305-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zeng, Kuan
Yu, Xuan
Mahaman, Yacoubou Abdoul Razak
Wang, Jian-Zhi
Liu, Rong
Li, Yi
Wang, Xiaochuan
Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
title Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
title_full Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
title_fullStr Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
title_full_unstemmed Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
title_short Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
title_sort defective mitophagy and the etiopathogenesis of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164340/
https://www.ncbi.nlm.nih.gov/pubmed/35655270
http://dx.doi.org/10.1186/s40035-022-00305-1
work_keys_str_mv AT zengkuan defectivemitophagyandtheetiopathogenesisofalzheimersdisease
AT yuxuan defectivemitophagyandtheetiopathogenesisofalzheimersdisease
AT mahamanyacoubouabdoulrazak defectivemitophagyandtheetiopathogenesisofalzheimersdisease
AT wangjianzhi defectivemitophagyandtheetiopathogenesisofalzheimersdisease
AT liurong defectivemitophagyandtheetiopathogenesisofalzheimersdisease
AT liyi defectivemitophagyandtheetiopathogenesisofalzheimersdisease
AT wangxiaochuan defectivemitophagyandtheetiopathogenesisofalzheimersdisease

Ejemplares similares