Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

BACKGROUND: Guanidinoacetate (GAA) induces epileptogenesis and neurotoxicity in the brain. As epileptic animal models have been reported to show elevated cerebral GAA levels, the processing mechanism of GAA in the brain is important for maintaining brain homeostasis. We have revealed that GAA in the...

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Detalles Bibliográficos
Autores principales: Jomura, Ryuta, Akanuma, Shin-ichi, Kubo, Yoshiyuki, Tachikawa, Masanori, Hosoya, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164341/
https://www.ncbi.nlm.nih.gov/pubmed/35658878
http://dx.doi.org/10.1186/s12987-022-00328-w

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