Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content

BACKGROUND: Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecules’ (folic acid and S-adenosylmethionine) availability can contribute to DNA m...

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Detalles Bibliográficos
Autores principales: Szigeti, Krisztina A., Kalmár, Alexandra, Galamb, Orsolya, Valcz, Gábor, Barták, Barbara K., Nagy, Zsófia B., Zsigrai, Sára, Felletár, Ildikó, V. Patai, Árpád, Micsik, Tamás, Papp, Márton, Márkus, Eszter, Tulassay, Zsolt, Igaz, Peter, Takács, István, Molnár, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164347/
https://www.ncbi.nlm.nih.gov/pubmed/35655145
http://dx.doi.org/10.1186/s12885-022-09659-1

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