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Inclusion body myositis and associated diseases: an argument for shared immune pathologies
Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do not classify IBM into different sub-entities, with the exception perhaps being the presence...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164382/ https://www.ncbi.nlm.nih.gov/pubmed/35659120 http://dx.doi.org/10.1186/s40478-022-01389-6 |
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author | Nelke, Christopher Kleefeld, Felix Preusse, Corinna Ruck, Tobias Stenzel, Werner |
author_facet | Nelke, Christopher Kleefeld, Felix Preusse, Corinna Ruck, Tobias Stenzel, Werner |
author_sort | Nelke, Christopher |
collection | PubMed |
description | Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do not classify IBM into different sub-entities, with the exception perhaps being the presence or absence of the anti-cN-1A-antibody. In contrast to other IIM, IBM is characterized by a chronic and progressive disease course. Here, we discuss the pathophysiological framework of IBM and highlight the seemingly prototypical situations where IBM occurs in the context of other diseases. In this context, understanding common immune pathways might provide insight into the pathogenesis of IBM. Indeed, IBM is associated with a distinct set of conditions, such as human immunodeficiency virus (HIV) or hepatitis C—two conditions associated with premature immune cell exhaustion. Further, the pathomorphology of IBM is reminiscent of other muscle diseases, notably HIV-associated myositis or granulomatous myositis. Distinct immune pathways are likely to drive these commonalities and senescence of the CD8(+) T cell compartment is discussed as a possible mechanism of pathogenesis. Future effort directed at understanding the co-occurrence of IBM and associated diseases could prove valuable to better understand the enigmatic IBM pathophysiology. |
format | Online Article Text |
id | pubmed-9164382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91643822022-06-05 Inclusion body myositis and associated diseases: an argument for shared immune pathologies Nelke, Christopher Kleefeld, Felix Preusse, Corinna Ruck, Tobias Stenzel, Werner Acta Neuropathol Commun Review Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do not classify IBM into different sub-entities, with the exception perhaps being the presence or absence of the anti-cN-1A-antibody. In contrast to other IIM, IBM is characterized by a chronic and progressive disease course. Here, we discuss the pathophysiological framework of IBM and highlight the seemingly prototypical situations where IBM occurs in the context of other diseases. In this context, understanding common immune pathways might provide insight into the pathogenesis of IBM. Indeed, IBM is associated with a distinct set of conditions, such as human immunodeficiency virus (HIV) or hepatitis C—two conditions associated with premature immune cell exhaustion. Further, the pathomorphology of IBM is reminiscent of other muscle diseases, notably HIV-associated myositis or granulomatous myositis. Distinct immune pathways are likely to drive these commonalities and senescence of the CD8(+) T cell compartment is discussed as a possible mechanism of pathogenesis. Future effort directed at understanding the co-occurrence of IBM and associated diseases could prove valuable to better understand the enigmatic IBM pathophysiology. BioMed Central 2022-06-03 /pmc/articles/PMC9164382/ /pubmed/35659120 http://dx.doi.org/10.1186/s40478-022-01389-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Nelke, Christopher Kleefeld, Felix Preusse, Corinna Ruck, Tobias Stenzel, Werner Inclusion body myositis and associated diseases: an argument for shared immune pathologies |
title | Inclusion body myositis and associated diseases: an argument for shared immune pathologies |
title_full | Inclusion body myositis and associated diseases: an argument for shared immune pathologies |
title_fullStr | Inclusion body myositis and associated diseases: an argument for shared immune pathologies |
title_full_unstemmed | Inclusion body myositis and associated diseases: an argument for shared immune pathologies |
title_short | Inclusion body myositis and associated diseases: an argument for shared immune pathologies |
title_sort | inclusion body myositis and associated diseases: an argument for shared immune pathologies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164382/ https://www.ncbi.nlm.nih.gov/pubmed/35659120 http://dx.doi.org/10.1186/s40478-022-01389-6 |
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