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α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function

BACKGROUND AND AIMS: Cholinergic output, which could modulate innate immune responses through stimulation of α7 nicotinic acetylcholine receptor (α7nAChR), might be a target to minimize tissue damage in autoimmune disease. GTS-21, a selective α7nAChR agonist, has previously demonstrated to inhibit s...

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Detalles Bibliográficos
Autores principales:	Ye, Ziping, Zhu, Yunjuan, Tang, Nana, Zhao, Xiaojing, Jiang, Jingyue, Ma, Jingjing, Zhang, Hongjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164421/ https://www.ncbi.nlm.nih.gov/pubmed/35659178 http://dx.doi.org/10.1186/s10020-022-00485-6

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