Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation

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The nucleocapsid (N) protein of coronaviruses is responsible for compaction of the ~30-kb RNA genome in the ~100-nm virion. Cryo-electron tomography suggests that each virion contains 35–40 viral ribonucleoprotein (vRNP) complexes, or ribonucleosomes, arrayed along the genome. There is, however, lit...

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Detalles Bibliográficos
Autores principales: Carlson, Christopher R., Adly, Armin N., Bi, Maxine, Cheng, Yifan, Morgan, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164447/
https://www.ncbi.nlm.nih.gov/pubmed/35664996
http://dx.doi.org/10.1101/2022.05.23.493138
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