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BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy

Immune checkpoint therapy (ICT) using antibody blockade of programmed cell death protein 1 (PD-1) or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) can provoke T cell–dependent antitumor activity that generates durable clinical responses in some patients. The epigenetic and transcriptional fea...

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Detalles Bibliográficos
Autores principales:	Salmon, Avery J., Shavkunov, Alexander S., Miao, Qi, Jarjour, Nicholas N., Keshari, Sunita, Esaulova, Ekaterina, Williams, Charmelle D., Ward, Jeffrey P., Highsmith, Anna M., Pineda, Josué E., Taneja, Reshma, Chen, Ken, Edelson, Brian T., Gubin, Matthew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164498/ https://www.ncbi.nlm.nih.gov/pubmed/35181783 http://dx.doi.org/10.1158/2326-6066.CIR-21-0129

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