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Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes

BACKGROUND: Endothelial dysfunction appears early in the development of cardiovascular disease and is associated with type 2 diabetes. We, therefore, tested the hypothesis that endothelial dysfunction is already present in healthy Chinese adolescent participants at risk of type 2 diabetes and associ...

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Autores principales: Wang, Yingwei, Li, Guangxia, Qi, Jing, Gong, Ting, Li, Xiudong, Liu, Fanghe, Bi, Xuejing, Zhao, Yang, Liang, Meihua, Zheng, Xiaodong, Qiao, Yuandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164499/
https://www.ncbi.nlm.nih.gov/pubmed/35659192
http://dx.doi.org/10.1186/s12872-022-02653-2
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author Wang, Yingwei
Li, Guangxia
Qi, Jing
Gong, Ting
Li, Xiudong
Liu, Fanghe
Bi, Xuejing
Zhao, Yang
Liang, Meihua
Zheng, Xiaodong
Qiao, Yuandong
author_facet Wang, Yingwei
Li, Guangxia
Qi, Jing
Gong, Ting
Li, Xiudong
Liu, Fanghe
Bi, Xuejing
Zhao, Yang
Liang, Meihua
Zheng, Xiaodong
Qiao, Yuandong
author_sort Wang, Yingwei
collection PubMed
description BACKGROUND: Endothelial dysfunction appears early in the development of cardiovascular disease and is associated with type 2 diabetes. We, therefore, tested the hypothesis that endothelial dysfunction is already present in healthy Chinese adolescent participants at risk of type 2 diabetes and associates with physical activity. METHODS: We investigated the flow-mediated dilation in 65 first-degree relatives (normal tension, normal glucose tolerance) and 62 age-, sex- and BMI-matched controls without a family history of type 2 diabetes by ultrasound. Physical activity level was assessed using the Global Physical Activity Questionaire and type 2 diabetes family history through self-reporting. The association between physical activity and flow-mediated dilation was evaluated by Pearson correlations and multiple regressions in adolescents with or without a family history of type 2 diabetes. RESULTS: Female adolescents display better flow-mediated dilation than males. Adolescents with a family history of type 2 diabetes had significantly impaired flow-mediated dilation than healthy controls. Among the parameter detection in the blood, the flow-mediated dilation is only positively associated with high-density lipoprotein cholesterol level, but not others. Interestingly, flow-mediated dilation is positively corrected with physical activity scores in both the male and female adolescents, while slightly impaired but not significant in adolescents with a family history of type 2 diabetes. CONCLUSION: Studies in adolescents are important to understand the early pathogenesis of type 2 diabetes. Findings of this investigation suggest that family history of type 2 diabetes may play a role in regulating the vascular function in Chinese adolescents. Given the impaired flow-mediated dilation in individuals with family history and the effects of physical activity in improved flow-mediated dilation, people with a family history of type 2 diabetes may need higher physical activity levels to attenuate their susceptibility to impaired flow-mediated dilation.
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spelling pubmed-91644992022-06-05 Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes Wang, Yingwei Li, Guangxia Qi, Jing Gong, Ting Li, Xiudong Liu, Fanghe Bi, Xuejing Zhao, Yang Liang, Meihua Zheng, Xiaodong Qiao, Yuandong BMC Cardiovasc Disord Research BACKGROUND: Endothelial dysfunction appears early in the development of cardiovascular disease and is associated with type 2 diabetes. We, therefore, tested the hypothesis that endothelial dysfunction is already present in healthy Chinese adolescent participants at risk of type 2 diabetes and associates with physical activity. METHODS: We investigated the flow-mediated dilation in 65 first-degree relatives (normal tension, normal glucose tolerance) and 62 age-, sex- and BMI-matched controls without a family history of type 2 diabetes by ultrasound. Physical activity level was assessed using the Global Physical Activity Questionaire and type 2 diabetes family history through self-reporting. The association between physical activity and flow-mediated dilation was evaluated by Pearson correlations and multiple regressions in adolescents with or without a family history of type 2 diabetes. RESULTS: Female adolescents display better flow-mediated dilation than males. Adolescents with a family history of type 2 diabetes had significantly impaired flow-mediated dilation than healthy controls. Among the parameter detection in the blood, the flow-mediated dilation is only positively associated with high-density lipoprotein cholesterol level, but not others. Interestingly, flow-mediated dilation is positively corrected with physical activity scores in both the male and female adolescents, while slightly impaired but not significant in adolescents with a family history of type 2 diabetes. CONCLUSION: Studies in adolescents are important to understand the early pathogenesis of type 2 diabetes. Findings of this investigation suggest that family history of type 2 diabetes may play a role in regulating the vascular function in Chinese adolescents. Given the impaired flow-mediated dilation in individuals with family history and the effects of physical activity in improved flow-mediated dilation, people with a family history of type 2 diabetes may need higher physical activity levels to attenuate their susceptibility to impaired flow-mediated dilation. BioMed Central 2022-06-03 /pmc/articles/PMC9164499/ /pubmed/35659192 http://dx.doi.org/10.1186/s12872-022-02653-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Yingwei
Li, Guangxia
Qi, Jing
Gong, Ting
Li, Xiudong
Liu, Fanghe
Bi, Xuejing
Zhao, Yang
Liang, Meihua
Zheng, Xiaodong
Qiao, Yuandong
Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes
title Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes
title_full Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes
title_fullStr Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes
title_full_unstemmed Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes
title_short Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes
title_sort decreased flow-mediated dilation in healthy chinese adolescent with a family history of type 2 diabetes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164499/
https://www.ncbi.nlm.nih.gov/pubmed/35659192
http://dx.doi.org/10.1186/s12872-022-02653-2
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