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Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report
BACKGROUND: We present a case of retinal occlusive vasculitis following brolucizumab administration and the first report of optical coherence tomography angiography (OCTA) findings after treatment. CASE PRESENTATION: A 71-year-old man complained of vision loss in the left eye 6 weeks after brolucizu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164534/ https://www.ncbi.nlm.nih.gov/pubmed/35659269 http://dx.doi.org/10.1186/s12886-022-02465-0 |
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author | Lee, Eun Kyoung Oh, Baek-Lok Yoon, Chang Ki Park, Un Chul |
author_facet | Lee, Eun Kyoung Oh, Baek-Lok Yoon, Chang Ki Park, Un Chul |
author_sort | Lee, Eun Kyoung |
collection | PubMed |
description | BACKGROUND: We present a case of retinal occlusive vasculitis following brolucizumab administration and the first report of optical coherence tomography angiography (OCTA) findings after treatment. CASE PRESENTATION: A 71-year-old man complained of vision loss in the left eye 6 weeks after brolucizumab injection. His visual acuity was counting fingers, and examination revealed 1 + anterior chamber cells with 2 + vitreous cells. Fundus examination demonstrated vitreous haze, retinal whitening, and vascular sheathing. Fluorescein angiography revealed filling defects in the retinal arteries and veins, and OCTA showed extensive capillary nonperfusion. Under the diagnosis of brolucizumab-associated intraocular inflammation (IOI) and retinal occlusive vasculitis, topical, sub-Tenon, and systemic corticosteroids were administered. After the treatment, visual acuity improved to 20/200, and OCTA revealed gradual improvement in capillary dropout; however, with the limited improvement of reperfusion in the perifoveal areas. CONCLUSIONS: Prompt evaluation and intensive corticosteroid treatments are required for brolucizumab-associated IOI. OCTA imaging provides detailed information on microvascular changes in the retinal vascular plexuses in brolucizumab-associated retinal occlusive vasculitis. |
format | Online Article Text |
id | pubmed-9164534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91645342022-06-05 Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report Lee, Eun Kyoung Oh, Baek-Lok Yoon, Chang Ki Park, Un Chul BMC Ophthalmol Case Report BACKGROUND: We present a case of retinal occlusive vasculitis following brolucizumab administration and the first report of optical coherence tomography angiography (OCTA) findings after treatment. CASE PRESENTATION: A 71-year-old man complained of vision loss in the left eye 6 weeks after brolucizumab injection. His visual acuity was counting fingers, and examination revealed 1 + anterior chamber cells with 2 + vitreous cells. Fundus examination demonstrated vitreous haze, retinal whitening, and vascular sheathing. Fluorescein angiography revealed filling defects in the retinal arteries and veins, and OCTA showed extensive capillary nonperfusion. Under the diagnosis of brolucizumab-associated intraocular inflammation (IOI) and retinal occlusive vasculitis, topical, sub-Tenon, and systemic corticosteroids were administered. After the treatment, visual acuity improved to 20/200, and OCTA revealed gradual improvement in capillary dropout; however, with the limited improvement of reperfusion in the perifoveal areas. CONCLUSIONS: Prompt evaluation and intensive corticosteroid treatments are required for brolucizumab-associated IOI. OCTA imaging provides detailed information on microvascular changes in the retinal vascular plexuses in brolucizumab-associated retinal occlusive vasculitis. BioMed Central 2022-06-03 /pmc/articles/PMC9164534/ /pubmed/35659269 http://dx.doi.org/10.1186/s12886-022-02465-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Lee, Eun Kyoung Oh, Baek-Lok Yoon, Chang Ki Park, Un Chul Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
title | Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
title_full | Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
title_fullStr | Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
title_full_unstemmed | Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
title_short | Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
title_sort | swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164534/ https://www.ncbi.nlm.nih.gov/pubmed/35659269 http://dx.doi.org/10.1186/s12886-022-02465-0 |
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