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Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats

BACKGROUND: Retinal neurodegeneration is induced by a variety of environmental insults and stresses, but the exact mechanisms are unclear. In the present study, we explored the involvement of cytosolic mitochondrial DNA (mtDNA), resulting in the cGAS-STING dependent inflammatory response and apoptos...

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Detalles Bibliográficos
Autores principales:	Guo, Yue, Gan, Dekang, Hu, Fangyuan, Cheng, Yun, Yu, Jian, Lei, Boya, Shu, Qinmeng, Gu, Ruiping, Xu, Gezhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164539/ https://www.ncbi.nlm.nih.gov/pubmed/35659309 http://dx.doi.org/10.1186/s40659-022-00390-6

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