CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. HTT mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of the basal ganglia. Transcript...

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Detalles Bibliográficos
Autores principales: Yu, Dahyun, Zarate, Nicole, White, Angel, Coates, De’jah, Tsai, Wei, Nanclares, Carmen, Cuccu, Francesco, Yue, Johnny S., Brown, Taylor G., Mansky, Rachel H., Jiang, Kevin, Kim, Hyuck, Nichols-Meade, Tessa, Larson, Sarah N., Gundry, Katherine, Zhang, Ying, Tomas-Zapico, Cristina, Lucas, Jose J., Benneyworth, Michael, Öz, Gülin, Cvetanovic, Marija, Araque, Alfonso, Gomez-Pastor, Rocio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164558/
https://www.ncbi.nlm.nih.gov/pubmed/35659303
http://dx.doi.org/10.1186/s40478-022-01379-8

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