EPEN-30. 5FU with Radiation Followed by Maintenance of 5FU and ATRA Significantly Improves Survival of 1q+/6q- PFA Ependymoma Xenograft Models

In a screen of over 100 FDA approved drugs on PFA 1q+ EPN cells, 5-fluorouracil (5FU) and All-Trans-Retinoic Acid (ATRA) were identified as inhibitors of EPN cell line growth. We performed in-vitro cell growth assays combining increasing doses of radiation and 5FU and found a significant synergistic...

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Detalles Bibliográficos
Autores principales: Grimaldo, Enrique, Donson, Andrew, Harris, Faith, Amani, Vladimir, Norris, Gregory, Steiner, Jenna, Serkova, Natalie, Dorris, Kathleen, Foreman, Nicholas, Griesinger, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164643/
http://dx.doi.org/10.1093/neuonc/noac079.166

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