HGG-13. Combined CDK inhibition and arginine-deprivation as targeted therapy for arginine-auxotrophic glioblastoma multiforme cells

INTRODUCTION/BACKGROUND: Glioblastoma multiforme show constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy. This renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase from Streptococcus pyogenes (SpyADI). Previously, we confirme...

Descripción completa

Detalles Bibliográficos
Autores principales: Riess, Christin, del Moral, Katharina, Fiebig, Adina, Kaps, Philipp, Linke, Charlotte, Hinz, Burkhard, Rupprecht, Anne, Frank, Markus, Fiedler, Tomas, Koczan, Dirk, Troschke-Meurer, Sascha, Lode, Holger N, Engel, Nadja, Classen, Carl Friedrich, Maletzki, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
High Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164690/
http://dx.doi.org/10.1093/neuonc/noac079.228

Ejemplares similares

Ejemplares similares