DIPG-40. Combined pharmacological and genetic screening to identify dependencies and combinations in ACVR1-mutant diffuse midline glioma

Somatic mutations in ACVR1, which encodes the serine/threonine kinase ALK2, are found in 20-25% of DMG-H3K27 patients. Treatment of ACVR1-mutant patient-derived models with multiple chemotypes of ALK2 inhibitors (ALK2i) results in reduced cell viability in vitro and extended survival in orthotopic x...

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Detalles Bibliográficos
Autores principales: Rogers, Rebecca, Carvalho, Diana, Grabovska, Yura, Fernandez, Elisabet, Izquierdo, Elisa, Mackay, Alan, Jones, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164693/
http://dx.doi.org/10.1093/neuonc/noac079.097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164693/
http://dx.doi.org/10.1093/neuonc/noac079.097

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