ETMR-12. Novel cell models of CNS tumors with BCOR fusion or internal tandem duplication suggest FGFR and PDGFR as promising therapy targets

Central nervous system (CNS) tumors with BCOR internal tandem duplications (CNS-BCOR ITD) are aggressive malignancies recently included in the 2021 WHO Classification of CNS tumors. This entity is characterized by ITDs within the PUFD domain of BCOR, potentially interfering with protein-protein inte...

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Detalles Bibliográficos
Autores principales: Kirchhofer, Dominik, Lötsch-Gojo, Daniela, Gabler, Lisa, Jaunecker, Carola N, Piontek, Martin, Mayr, Lisa, Englinger, Bernhard, Pirker, Christine, Mohr, Thomas, Lämmerer, Anna, Schmitt-Hoffner, Felix, Boidol, Bernd, Kubiceck, Stefan, Peyrl, Andreas, Azizi, Amadeo A, Dorfer, Christian, Haberler, Christine, Kool, Marcel, Berger, Walter, Gojo, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
ETMR and other Embryonal Tumors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164729/
http://dx.doi.org/10.1093/neuonc/noac079.190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164729/
http://dx.doi.org/10.1093/neuonc/noac079.190

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