MEDB-52. Organoids as preclinical models to improve and personalize disease outcome for sonic hedgehog medulloblastoma

Four main medulloblastoma (MB) molecular subgroups are known, including the sonic hedgehog (SHH) subgroup, which represents ~25% of MB cases. The 5-year overall survival of SHH-MB is ~80%. However, survival between patients is highly diverse and dependent on the driver mutation(s) of the tumor. Pati...

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Autores principales: Odé, Zelda, Maas, Joris, Roosen, Mieke, Stathi, Phylicia, Federico, Aniello, Mack, Norman, Schwalm, Benjamin, Bunt, Jens, Kool, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164751/
http://dx.doi.org/10.1093/neuonc/noac079.426

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