MEDB-08. Inhibition of different mitotic targets demonstrated distinct DNA damage and cell death response in p53-mutant medulloblastoma

BACKGROUND: In normal cells, cell cycle is tightly regulated by mitotic proteins to ensure smooth transition through each phase of cell division. Here, we examine two proteins – KIF11, a mitotic kinesin, responsible for assembly and maintenance of mitotic spindle during mitosis; and MELK, a serine/t...

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Detalles Bibliográficos
Autores principales: Huang, Shiying, Pan, Jie-Ling, Karthik, Sekar, Du, YuChen, Lin, Qi, Lau, Ching C, Adekunle, Adesina, Su, Jack M F, Major, Angela, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164819/
http://dx.doi.org/10.1093/neuonc/noac079.383

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