MEDB-28. CDK9 is a druggable mediator sustaining Myc-driven circuitry in medulloblastoma

BACKGROUND: Though long recognized as a master regulator of cell proliferation across a wide range of cancers, Myc has proven elusive to direct therapeutic targeting. The CDK9-containing PTEFb, complexed with either BRD4 or SEC, facilitates Myc-driven transcriptional programs and is necessary for su...

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Detalles Bibliográficos
Autores principales: Madhavan, Krishna, Walker, Faye, Wang, Dong, Sobral, Lays Martin, Balakrishnan, Ilango, Pierce, Angela, Serkova, Natalie, Foreman, Nicholas, Venkataraman, Sujatha, Vibhakar, Rajeev, Dahl, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164830/
http://dx.doi.org/10.1093/neuonc/noac079.402

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