A novel phenotype‐based drug‐induced liver injury causality assessment tool (DILI‐CAT) allows for signal confirmation in early drug development

BACKGROUND: Drug‐induced liver injury (DILI) requires accurate case adjudication, with expert opinion being the current best practice. AIM: We utilised a novel DILI causality assessment tool (DILI‐CAT), which uses drug‐specific liver injury phenotypes, to examine potential DILI in early phase ximela...

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Detalles Bibliográficos
Autores principales: Hermann, Richard P., Rockey, Don C., Suzuki, Ayako, Merz, Michael, Tillmann, Hans L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Dili‐cat ‐ a New Tool for Detection of Early Drug Induced Liver Injury
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164935/
https://www.ncbi.nlm.nih.gov/pubmed/35266155
http://dx.doi.org/10.1111/apt.16836

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