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INSP-01. What to do when you cannot randomize? Leveraging Historical Data in Efficient Study Designs for Pediatric Neuro-Oncology.
BACKGROUND: Randomized phase III studies represent the gold standard in clinical trial design for many good reasons. They control bias and the effects of known and unknown covariates on outcomes of interest. Recent examples from Children’s Oncology Group Medulloblastoma studies have demonstrated the...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164970/ http://dx.doi.org/10.1093/neuonc/noac079.697 |