IMMU-13. Dual CTLA4/ PD-1 blockade improves survival for replication-repair deficient high-grade gliomas failing single agent PD-1 inhibition: An IRRDC study

BACKGROUND: High-grade gliomas (HGG) with replication-repair deficiency (RRD) harbour high mutation burden (TMB) and are rapidly fatal following chemo-radiation approaches. Although hypermutation results in objective responses and prolonged survival in >30% of patients undergoing PD1-blockade, sa...

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Autores principales: Das, Anirban, Morgenstern, Daniel, Bianchi, Vanessa, Sudhaman, Sumedha, Edwards, Melissa, Stengs, Lucie, Larouche, Valerie, Samuel, David, Van Damme, An, Gass, David, Ziegler, David, Bielack, Stefan, Zelcer, Shayna, Yalon, Michal, Constantini, Shlomi, Sarosiek, Tomasz, Libionka, Witold, Nichols, Kim, De Mola, Rebecca Loret, Bielamowicz, Kevin, Sabel, Magnus, Frojd, Charlotta, Wood, Matthew D, Migueis, Joana Cristiano Sous, Abongwa, Chenue, Yen, Lee Yi, Stearns, Duncan, Opocher, Enrico, Bhatia, Kanika, Sen, Santanu, Cantero, Eduardo Quiroga, Paez, Palma Solano, Crooks, Bruce, Magimairajan, Vanan, Reddy, Alyssa, Adamski, Jenny, Mason, Gary, Lindhorst, Scott, Aronson, Melyssa, Ertl-Wagner, Birgit, Hawkins, Cynthia, Bouffet, Eric, Tabori, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164997/
http://dx.doi.org/10.1093/neuonc/noac079.306

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