EPCT-05. Phase Ib study of unesbulin (PTC596) in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG): A report from the COllaborative Network for NEuro-Oncology Clinical Trials (CONNECT)

BACKGROUND: The B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) protein, implicated in self-renewal and DNA-damage signaling, is highly expressed in DIPG and HGG. Preclinically, BMI-1 modulation by unesbulin (PTC596 [which mediates hyperphosphorylation and subsequent degrada...

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Detalles Bibliográficos
Autores principales: Lazow, Margot A, Baxter, Patricia, Stanek, Joseph, Lane, Adam, Rodriguez, Diana P, Kumar, Shiva Senthil, Leach, James L, Mikael, Leonie, Fuller, Christine, Boué, Daniel R, Pierson, Christopher R, Thomas, Diana, Breneman, John, Palmer, Joshua, Li, Xiao-Nan, Salloum, Ralph, Ashley, David, de Blank, Peter, Hwang, Eugene, Leary, Sarah E S, Plant, Ashley, Crabtree, Dorothy, Wahba, Mona, Weetall, Marla, Baird, John, Leonard, Jeffrey, Stewart, Clinton F, Mardis, Elaine, Fouladi, Maryam, Drissi, Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Early Phase Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165000/
http://dx.doi.org/10.1093/neuonc/noac079.133

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