MODL-06. Targeting c-MET in combination with radiation is effective in MET-fusion driven high-grade glioma

Oncogenic fusion events involving c-MET have been observed in up to 12% of pediatric high-grade glioma (pHGG). MET inhibitors have displayed potent initial responses in MET rearranged tumors but acquired resistance to single agent modalities invariably occurs. To identify new treatment options again...

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Detalles Bibliográficos
Autores principales: Zuckermann, Marc, He, Chen, Andrews, Jared, Sloan-Henry, Roketa, Bianski, Brandon, Xie, Jia, Wang, Yingzhe, Twarog, Nathaniel, Onar-Thomas, Arzu, Ernst, Kati, Yang, Lei, Li, Yong, Dalton, James, Li, Xiaoyu, Chepyala, Divyabharathi, Zhu, Xiaoyan, Zhang, Junyuan, Xu, Ke, Hover, Laura, McKinnon, Peter J, Pfister, Stefan M, Rankovic, Zoran, Freeman, Burgess B, Shelat, Anang A, Chiang, Jason, Jones, David T W, Tinkle, Christopher L, Baker, Suzanne J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165032/
http://dx.doi.org/10.1093/neuonc/noac079.629

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