MODL-02. A novelCre-conditionalcMYC-driven MB Group 3 transgenic mouse model shows traceable leptomeningeal dissemination.

Medulloblastoma (MB), the most common embryonal tumour of the Central Nervous System, occurs in the cerebellum. Treatment regimens involve surgery, craniospinal radiotherapy, and chemotherapy. The greatest mortality is associated with disseminated disease, almost exclusively found in the leptomening...

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Detalles Bibliográficos
Autores principales: Morcavallo, Alaide, Barker, Karen, Kwok, Colin, Boult, Jessica K R, da Silva, Patricia Benites Goncalves, Okonechnikov, Konstantin, Zuckermann, Marc, Gorrini, Chiara, Jacques, Thomas S, Robinson, Simon P, Clifford, Steven C, Weiss, William A, Pfister, Stefan M, Kawauchi, Daisuke, Chesler, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165051/
http://dx.doi.org/10.1093/neuonc/noac079.625

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