MEDB-57.GNAS inactivation as a driver for sonic hedgehog-activated medulloblastoma

INTRODUCTION: Sonic hedgehog (SHH)-activated medulloblastoma is one of the four consensus molecular subgroups of medulloblastoma and is typically associated with PTCH1, SUFU, and/or SMO mutations. GNAS inactivating mutations are a less commonly recognized tumorigenic driver for SHH pathway activatio...

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Autores principales: Goode, Erin, Montoya, Liliana, Graham, Eric, Pruniski, Brianna, Simmons, Curtis, Ngwube, Alexander, Hoffman, Lindsey M, Tiwari, Nishant, Aldape, Kenneth, Price, Harper N, Paulson, Vera, Mangum, Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165066/
http://dx.doi.org/10.1093/neuonc/noac079.431

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