LGG-59. Identifying hidden drivers of low-grade glioma tumor growth

Genomic drivers of pediatric low-grade gliomas (pLGGs) converge on alterations that activate the MAPK pathway. However, expression of individual driver oncogenes fails to induce tumor formation with high penetrance and, paradoxically, expression of these oncogenes suppresses growth in vitro. This, c...

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Detalles Bibliográficos
Autores principales: Misek, Sean, Fultineer, Aaron, Condurat, Alexandra, Zhou, Kevin, Root, David, Persky, Nicole, Boehm, Jesse, Bandopadhayay, Pratiti, Beroukhim, Rameen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Low Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165109/
http://dx.doi.org/10.1093/neuonc/noac079.370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165109/
http://dx.doi.org/10.1093/neuonc/noac079.370

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