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MODL-01. Targeting replication stress in pediatric brain tumors

Previously, we have found that Embryonal Tumors with Multilayered Rosettes (ETMR) tumor cells harboring high levels of R-loops, a potential marker for replication stress and genomic instability, are vulnerable to a combination of topoisomerase and PARP inhibitors. To follow up on this, we investigat...

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Detalles Bibliográficos
Autores principales:	Krausert, Sonja, Mack, Norman, Schwalm, Benjamin, Peterziel, Heike, Oehme, Ina, van Tilburg, Cornelis M, Witt, Olaf, Pfister, Stefan M, Kool, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165149/ http://dx.doi.org/10.1093/neuonc/noac079.624

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