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HGG-02. Epigenetic transcription regulation and 3D genome structure in pediatric high-grade glioma
INTRODUCTION: Pediatric high-grade gliomas (pHGGs), including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), are highly morbid brain tumors. Up to 80% of DIPGs harbor a somatic missense mutation in genes encoding Histone H3. To investigate whether the H3K27M mutant protei...
Autores principales: | Huang, Tina, Wang, Juan, Hu, Ye, Piunti, Andrea, Bartom, Elizabeth, Shilatifard, Ali, Yue, Feng, Saratsis, Amanda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165162/ http://dx.doi.org/10.1093/neuonc/noac079.218 |
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