EPCT-06. Phase I study of ribociclib and everolimus post-radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG): Updated report from the COllaborative Network for NEuro-Oncology Clinical Trials (CONNECT)

BACKGROUND: Dual inhibition of CDK4/6 and mTOR in DIPG and pediatric HGG has strong biologic rationale, given prevalent genetic alterations resulting in upregulated cell cycle and PI3K/mTOR pathways in these diseases, as well as non-overlapping agent toxicities. This study sought to evaluate safety/...

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Detalles Bibliográficos
Autores principales: Lazow, Margot A, DeWire, Mariko, Campagne, Olivia, Leach, James L, Fuller, Christine, Kumar, Shiva Senthil, Stanek, Joseph, de Blank, Peter, Hummel, Trent R, Pillay-Smiley, Natasha, Salloum, Ralph, Stevenson, Charles B, Baxter, Patricia, Gass, David, Goldman, Stewart, Leary, Sarah E S, Carle, Adam, Lane, Adam, Drissi, Rachid, Stewart, Clinton, Fouladi, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Early Phase Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165190/
http://dx.doi.org/10.1093/neuonc/noac079.134

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