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Bayesian graphical models for modern biological applications

Graphical models are powerful tools that are regularly used to investigate complex dependence structures in high-throughput biomedical datasets. They allow for holistic, systems-level view of the various biological processes, for intuitive and rigorous understanding and interpretations. In the conte...

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Autores principales: Ni, Yang, Baladandayuthapani, Veerabhadran, Vannucci, Marina, Stingo, Francesco C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165295/
https://www.ncbi.nlm.nih.gov/pubmed/35673326
http://dx.doi.org/10.1007/s10260-021-00572-8
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author Ni, Yang
Baladandayuthapani, Veerabhadran
Vannucci, Marina
Stingo, Francesco C.
author_facet Ni, Yang
Baladandayuthapani, Veerabhadran
Vannucci, Marina
Stingo, Francesco C.
author_sort Ni, Yang
collection PubMed
description Graphical models are powerful tools that are regularly used to investigate complex dependence structures in high-throughput biomedical datasets. They allow for holistic, systems-level view of the various biological processes, for intuitive and rigorous understanding and interpretations. In the context of large networks, Bayesian approaches are particularly suitable because it encourages sparsity of the graphs, incorporate prior information, and most importantly account for uncertainty in the graph structure. These features are particularly important in applications with limited sample size, including genomics and imaging studies. In this paper, we review several recently developed techniques for the analysis of large networks under non-standard settings, including but not limited to, multiple graphs for data observed from multiple related subgroups, graphical regression approaches used for the analysis of networks that change with covariates, and other complex sampling and structural settings. We also illustrate the practical utility of some of these methods using examples in cancer genomics and neuroimaging.
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spelling pubmed-91652952022-06-05 Bayesian graphical models for modern biological applications Ni, Yang Baladandayuthapani, Veerabhadran Vannucci, Marina Stingo, Francesco C. Stat Methods Appt Review Paper Graphical models are powerful tools that are regularly used to investigate complex dependence structures in high-throughput biomedical datasets. They allow for holistic, systems-level view of the various biological processes, for intuitive and rigorous understanding and interpretations. In the context of large networks, Bayesian approaches are particularly suitable because it encourages sparsity of the graphs, incorporate prior information, and most importantly account for uncertainty in the graph structure. These features are particularly important in applications with limited sample size, including genomics and imaging studies. In this paper, we review several recently developed techniques for the analysis of large networks under non-standard settings, including but not limited to, multiple graphs for data observed from multiple related subgroups, graphical regression approaches used for the analysis of networks that change with covariates, and other complex sampling and structural settings. We also illustrate the practical utility of some of these methods using examples in cancer genomics and neuroimaging. Springer Berlin Heidelberg 2021-05-27 2022 /pmc/articles/PMC9165295/ /pubmed/35673326 http://dx.doi.org/10.1007/s10260-021-00572-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Paper
Ni, Yang
Baladandayuthapani, Veerabhadran
Vannucci, Marina
Stingo, Francesco C.
Bayesian graphical models for modern biological applications
title Bayesian graphical models for modern biological applications
title_full Bayesian graphical models for modern biological applications
title_fullStr Bayesian graphical models for modern biological applications
title_full_unstemmed Bayesian graphical models for modern biological applications
title_short Bayesian graphical models for modern biological applications
title_sort bayesian graphical models for modern biological applications
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165295/
https://www.ncbi.nlm.nih.gov/pubmed/35673326
http://dx.doi.org/10.1007/s10260-021-00572-8
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