MEDB-01. Management of the risk of medulloblastoma associated to familial adenomatous polyposis and dysregulated Wnt signalosome

APC is the key gene of the familial adenomatous polyposis (FAP). This tumor suppressor gene functions by negatively regulating the β-catenin protein and the majority of APC mutations disrupt the β-catenin degradation complex signalosome leading to the activation of the canonical Wnt pathway. Pathoge...

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Detalles Bibliográficos
Autores principales: Abdelmoula, Balkiss, Abid, Fatma, Karra, Amir, Kammoun, Sonda, Aloulou, Samir, Abdelmoula, Nouha Bouayed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165304/
http://dx.doi.org/10.1093/neuonc/noac079.376

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