HGG-32. Durable response to mTOR inhibitor after failing Checkpoint inhibitors in Ultra-Hypermutated High grade glioma in context of CMMRD

BACKGROUND: Paediatric High Grade Gliomas (HGG) have poor outcomes with conventional treatment. HGG in association with constitutional DNA mismatch repair deficiency (CMMRD) are hypermutated and have shown dramatic response to checkpoint inhibitors. Salvage following progression or failure to respon...

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Detalles Bibliográficos
Autores principales: Hegde, Kriti, Dahl, Christine, Depani, Sarita, Hargrave, Darren, Oostveen, Minou, Aguirregomezcorta, Fernando, Jeelani, Owase, Aquilina, Kristian, Gains, Jenny, Ching, Yen, Jacues, Thomas, Merve, Ashirwad, Chalker, Jane, Addy, Dilys, Ahmed, Saira W, Yasin, Shireen, Mankad, Kshitij, Carney, Olivia, Sudhakar, Sniya, D'Arco, Felice, Loebel, Ulrike, Jorgensen, Mette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
High Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165311/
http://dx.doi.org/10.1093/neuonc/noac079.247

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