ETMR-14. The single-cell landscape of pineoblastoma identifies developmental origins and exposes novel therapeutic vulnerabilities.

Pineoblastoma (PB) is a rare and aggressive childhood brain tumor with highly variable age and treatment-associated outcomes. Our recent bulk tumor analyses of DNA methylation and mutational landscapes uncovered four discrete PB molecular subgroups (PB-miRNA1, PB-miRNA2, PB-MYC/FOXR2, and PB-RB), pr...

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Detalles Bibliográficos
Autores principales: Gudenas, Brian, Englinger, Bernhard, Liu, Anthony P Y, Ahmad, Sheikh Tanveer, Meredith, David, Pfaff, Elke, Paul, Leena, Hadley, Jennifer, Batts, Melissa, Klimo, Paul, Boop, Frederick A, Gajjar, Amar, Robinson, Giles, Orr, Brent, Lin, Hong, Alexandrescu, Sanda, Jones, David T W, Filbin, Mariella G, Northcott, Paul A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
ETMR and other Embryonal Tumors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165319/
http://dx.doi.org/10.1093/neuonc/noac079.192

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