Acoustofluidic Stimulation of Functional Immune Cells in a Microreactor (Adv. Sci. 16/2022)

Acoustofluidic Stimulation of Functional Immune Cells In article number 2105809, Jinsoo Park, Hyung Jin Sung, Jessie S. Jeon, and co‐workers employ surface acoustic waves to agitate fluid in a microreactor capable of dynamic cell culture in a controllable and contact‐free manner. This microreactor prevents cellular damages that can be seen in the acoustic vortex by adjusting the duty cycle and applied power of the acoustical actuation. Using the microreactor, the functional changes of natural killer cells are observed upon the acoustical stimulation, namely, Ca(2+) influx to the cells and their enhanced cell‐mediated cytotoxicity to the tumor cells in the copresence of protein kinase C activator. [Image: see text]