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Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel

Untethered small robots with multiple functions show considerable potential as next‐generation catheter‐free systems for biomedical applications. However, owing to dynamic blood flow, even effective upstream swimming in blood vessels remains a challenge for the robot, let alone performing medical ta...

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Autores principales: Yang, Liu, Zhang, Tieshan, Tan, Rong, Yang, Xiong, Guo, Dong, Feng, Yu, Ren, Hao, Tang, Yifeng, Shang, Wanfeng, Shen, Yajing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165508/
https://www.ncbi.nlm.nih.gov/pubmed/35355442
http://dx.doi.org/10.1002/advs.202200342
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author Yang, Liu
Zhang, Tieshan
Tan, Rong
Yang, Xiong
Guo, Dong
Feng, Yu
Ren, Hao
Tang, Yifeng
Shang, Wanfeng
Shen, Yajing
author_facet Yang, Liu
Zhang, Tieshan
Tan, Rong
Yang, Xiong
Guo, Dong
Feng, Yu
Ren, Hao
Tang, Yifeng
Shang, Wanfeng
Shen, Yajing
author_sort Yang, Liu
collection PubMed
description Untethered small robots with multiple functions show considerable potential as next‐generation catheter‐free systems for biomedical applications. However, owing to dynamic blood flow, even effective upstream swimming in blood vessels remains a challenge for the robot, let alone performing medical tasks. This paper presents an untethered millirobot with a streamlined shape that integrates the engine, delivery, and biopsy modules. Based on the proposed spiral‐rolling strategy, this robot can move upstream at a record‐breaking speed of ≈14 mm s(−1) against a blood phantom flow of 136 mm s(−1). Moreover, benefiting from the bioinspired self‐sealing orifice and easy‐open auto‐closed biopsy needle sheath, this robot facilitates several biomedical tasks in blood vessels, such as in vivo drug delivery, tissue and liquid biopsy, and cell transportation in rabbit arteries. This study will benefit the development of wireless millirobots for controllable, minimally invasive, highly integrated, and multifunctional endovascular interventions and will inspire new designs of miniature devices for biomedical applications.
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spelling pubmed-91655082022-06-04 Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel Yang, Liu Zhang, Tieshan Tan, Rong Yang, Xiong Guo, Dong Feng, Yu Ren, Hao Tang, Yifeng Shang, Wanfeng Shen, Yajing Adv Sci (Weinh) Research Articles Untethered small robots with multiple functions show considerable potential as next‐generation catheter‐free systems for biomedical applications. However, owing to dynamic blood flow, even effective upstream swimming in blood vessels remains a challenge for the robot, let alone performing medical tasks. This paper presents an untethered millirobot with a streamlined shape that integrates the engine, delivery, and biopsy modules. Based on the proposed spiral‐rolling strategy, this robot can move upstream at a record‐breaking speed of ≈14 mm s(−1) against a blood phantom flow of 136 mm s(−1). Moreover, benefiting from the bioinspired self‐sealing orifice and easy‐open auto‐closed biopsy needle sheath, this robot facilitates several biomedical tasks in blood vessels, such as in vivo drug delivery, tissue and liquid biopsy, and cell transportation in rabbit arteries. This study will benefit the development of wireless millirobots for controllable, minimally invasive, highly integrated, and multifunctional endovascular interventions and will inspire new designs of miniature devices for biomedical applications. John Wiley and Sons Inc. 2022-03-31 /pmc/articles/PMC9165508/ /pubmed/35355442 http://dx.doi.org/10.1002/advs.202200342 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Yang, Liu
Zhang, Tieshan
Tan, Rong
Yang, Xiong
Guo, Dong
Feng, Yu
Ren, Hao
Tang, Yifeng
Shang, Wanfeng
Shen, Yajing
Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel
title Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel
title_full Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel
title_fullStr Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel
title_full_unstemmed Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel
title_short Functionalized Spiral‐Rolling Millirobot for Upstream Swimming in Blood Vessel
title_sort functionalized spiral‐rolling millirobot for upstream swimming in blood vessel
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165508/
https://www.ncbi.nlm.nih.gov/pubmed/35355442
http://dx.doi.org/10.1002/advs.202200342
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